Fmr1 deletion enhances and ultimately desensitizes CB1 signaling in autaptic hippocampal neurons
نویسندگان
چکیده
منابع مشابه
Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons.
Fragile X Syndrome (FXS) is a heritable form of mental retardation caused by a non-coding trinucleotide expansion of the FMR1 gene leading to loss of expression of this RNA binding protein. Mutations in this gene are strongly linked to enhanced Group I metabotropic glutamate receptor (mGluR) signaling. A recent report found that mGluR5-dependent endogenous cannabinoid signaling is enhanced in h...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2013
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2013.04.002